ICCAI: Session I
| Title: | Abstractions: Inflammation and Sepsis | |||
| Date: | Saturday, June 28 | |||
| Time: | 09:15 - 10:50 | |||
| Hall: | W-R-Museum, Stiftersaal | |||
| Chair: | E.A.M. Neugebauer Y. Vodovotz | |||
| 09:15-09:25 | Insights from Computational simulations of the acute inflammatory response | |||
| 09:30-09:45 | An ensemble of models of the acute inflammatory response S. Daun, J. Rubin, A. Roy, J. Kellum, R. Parker, G. Clermont | |||
| 09:50-10:05 | Computational simulation of individual inflammation and outcomes in trauma patients | |||
| 10:10-10:30 | Agent-based model of lung inflammation | |||
| 10:35-10:50 | Discussion: What is an ideal abstraction? What must the abstraction account for? | |||
ICCAI: Session II
| Title: | Untangling Inflammation from Infection | |
| Date: | Saturday, June 28 | |
| Time: | 11:15 - 13:00 | |
| Hall: | W-R-Museum, Stiftersaal | |
| Chair: | A. Nierhaus G. An | |
| 11:15-11:35 | The transcriptome: Riboleukography | |
| 11:40-11:55 | Temporal analysis of signaling pathways in multiple organ failure | |
| 12:00-12:15 | St-2-dynamics and endotoxin tolerance modelling | |
| 12:20-12:40 | The riddle of endocrine pulsatility: why does it exist? | |
| 12:45-13:00 | Discussion: In acute illness, how do we distinguish inflammation from infection? What do models tell us? | |
ICCAI: Session III
| Title: | Variability: Predictions | |
| Date: | Saturday, June 28 | |
| Time: | 14:00 - 16:00 | |
| Hall: | W-R-Museum, Stiftersaal | |
| Chair: | T.G. Buchman V. Papaioannou | |
| 14:00-14:10 | Visualization of multi-dimensional complex physiologic states using bioinformatic cluster analysis M. Cohen | |
| 14:15-14:25 | Early loss of complexity is associated with ventilator-associated pneumonia in 2032 trauma patients | |
| 14:30-14:40 | Pre-treatment with a stress-dose but not a high dose infusion of hydrocortisone maintains heart rate variability during human endotoxemia | |
| 14:45-14:55 | Exploration of heart-rate complexity to determine the need for lifesaving interventions in combat casualties A. Batchinsky, J. Salinas, J. Skinner, D. Weiss, C. Wade, J. Holcomb, L. Cancio | |
| 15:00-15:10 | Early Detection of infection with continuous heart rate variability analysis in neutropenic patients | |
| 15:15-15:25 | Relation of heart rate variability to serum levels of C-reactive protein in patients with severe sepsis and septic shock V. Papaionannou, C. Dragoumanis, I. Pneumatikos | |
| 15:30-15:40 | Do non-linear measures of heart rate variability (HRV) track muscle sympathetic nerve activity (MSNA) during central hypovolemia in humans? C.A. Rickards, K.L. Ryan, W.H. Cooke, V.A. Convertino | |
| 15:45-16:00 | Discussion: If compromised physiologic variability is clinically important, what is needed to get it more widely accessible/used? | |
Poster Session
| Title: | ICCAI - 14 Posters | |
| Date: | Saturday, June 28 | |
| Time: | 16:00 - 17:15 | |
| Hall: | W-R-Museum, Stiftersaal | |
| 1. | Severe sepsis and septic shock during pregnancy and puerperium: the incidence, the etiology and the outcome | |
| 2. | Correlation between adiponectin and apache-II in patients with intra-abdominal sepsis | |
| 3. | Resistin is increased in intra abdominal sepsis: correlation with proinflamatuary cytokines and apache-II scores | |
| 4. | Natural history of disseminated intravascular coagulation diagnosed by the newly established diagnostic criteria for critically ill patients | |
| 5. | Ergothioneine prevents acute lung injury in mesenteric ischemia and reperfusion injury in rats | |
| 6. | Establishment of an acute superior mesenteric artery injury model for damage control surgery | |
| 7. | Temporary intravascular shunts as a damage control adjunct to maintain intestine perfusion after superior mesenteric artery injury in swine model W. Ding, X. Wu, J. Li | |
| 8. | A closed loop model of pulmonary gas exchange | |
| 9. | Mesenteric microcirculatory dysfunction associated with indigenous bacterial translocation after intestinal obstruction and ischemia in rats | |
| 10. | Immune response to influenza A | |
| 11. | Lip polysaccharide-caused neurodegenerative diseases | |
| 12. | Short-term regulation of the cardiovascular system: an ode based model | |
ICCAI: Session IV
| Title: | Modeling: Frontiers | |
| Date: | Sunday, June 29 | |
| Time: | 09:00 - 10:50 | |
| Hall: | W-R-Museum, Stiftersaal | |
| Chair: | K. Brohi C. Vasilescu | |
| 09:00-09:10 | In silicio clinical trials in sepsis | |
| 09:15-09:30 | Unbiased inference of parameter distributions for non-linear models: the underdetermined case | |
| 09:35-09:50 | Bio-cartogramography to present complex physiological data sets | |
| 09:55-10:10 | Optimizing hem adsorption therapy with model predictive control J. Hogg, G. Clermont, J. Kellum, R. Parker | |
| 10:15-10:30 | Biological complexity and analytical techniques to promote simplification and understandings | |
| 10:35-10:50 | Discussion: What is needed? New techniques? Adapted techniques? Different questions? Testable hypotheses? | |
ICCAI: Session V
| Title: | Spectroscopy | |||
| Date: | Sunday, June 29 | |||
| Time: | 11:10 - 13:00 | |||
| Hall: | W-R-Museum, Stiftersaal | |||
| Chair: | W. Petrich H. Mertsching | |||
| 11:10-11:20 | FT-IR, Raman and such - a 10-minute guide through the spectroscopy of molecular vibrations | |||
| 11:25-11:45 | Characterization of autologous transplants by Raman spectroscopy | |||
| 11:50-12:10 | Rapid identification of pathogens from blood cultures by FT-IR Microspectroscopy: a prospective study D. Naumann | |||
| 12:15-12:35 | Clinical triaging of acute chest pain patients by means of infrared spectroscopy W. Petrich | |||
| 12:40-13:00 | Discussion: How can spectroscopy illuminate complexity in acute illness? | |||
Symposium - Merck Sharp & Dohme (MSD)
| Title: | Evidence Based Anti-Infective Strategies | ||
| Date: | Sunday, June 29 | ||
| Time: | 11:30 - 13:00 | ||
| Hall: | Guerzenich, Horton Hall | ||
| Chair: | C. Putensen, Bonn, Germany | ||
| 11:30-11:50 | Epidemiology | C. Putensen | |
| 11:50-12:10 | Antibacterial strategies in sepsis | T. Welte | |
| 12:10-12:30 | Antimycotic strategies in the ICU | E. Mueller | |
| 12:30-13:00 | Discussion | ||
Workshop I
| Title: | Mathematical Modeling of Inflammation | |
| Date: | Sunday, June 29 | |
| Time: | 13:30 - 18:00 | |
| Hall: | W-R-Museum, Stiftersaal | |
| Chair: | G. Clermont G. An | |
| 13:30 | Introduction: Multiple scales call for multiple methods | G. Clermont G. An |
| 13:40 | Network models: From genes to cells | M. Cohen / K. Brohi |
| 13:50 | Agent based models: From pathways to tissues | G. An |
| 14:00 | Stochastic models: Capturing the richness of biological behavior | G. An |
| 14:10 | Differential Equation models | J. Sarkar |
| 14:20 | From an individual to a population | G. Clermont |
| 14:30 | Interactive Session: Developing models of the pulmonary response to acute inflammation at multiple levels of resolution | Panel members and workshop attendees |
Workshop II - Siemens Medical Solutions DX
| Title: | Measurement of Inflammation/Sepsis in Critically ill Patients | |||
| Date: | Sunday, June 29 | |||
| Time: | 13:00 - 18:00 | |||
| Hall: | Guerzenich, | |||
| Chair: | E. Faist M. van Griensven | |||
| 13:00-13:30 | IL6 and other biochemical markers in a sugical ICU | E. Faist | ||
| 13:30-14:00 | Laboratory diagnostics with IL6 and LBP at a trauma ICU: Decision making between SIRS, sepsis and OP-management | M. van Griensven | ||
| 14:00-14:30 | Infection and sepsis diagnostics in intensive care medicine | D. Schmidt | ||
| 14:30-15:00 | Sepsis and Immunsystem - Terra incognita | A. Spittler | ||
| 15:00-18:00 | Practical demonstration of serum measurements of IL6 and LBP | |||
Workshop III - SIRS Lab GmbH
| Title: | Microarray - Tool or Toy | |
| Date: | Sunday, June 29 | |
| Time: | 13:00 - 18:15 | |
| Hall: | Guerzenich | |
| Chair: | M. Bauer C. Thiemermann | |
| 13:00 | Welcome / Introduction | Chairmen |
| 13:15-14:00 | A bird eye´s view on RNomics | F. Horn |
| 14:00-14:30 | Experiments using microarrays - is there a gold standard for biostatitistics? | M. Kohl |
| 14:30-15:00 | Integrating transcriptomics and simulations in shock states | Y. Vodovotz |
| 15:15-16:00 | Monocyte gene expression profiles after multiple trauma - a genome wide approach | P. Biberthaler |
| 16:00-16:45 | H2S modulates ischemia/reperfusion injury of the heart | C. Thiemermann |
| 17:00-17:45 | RNomics at the bedside - the infection host response continuum | M. Bauer |
| 17:45-18:15 | Panel discussion - hopes and limitations of RNomics | all speakers |
Workshop IV
| Title: | Evidence-based Medicine | |
| Date: | Sunday, June 29 | |
| Time: | 13:00 - 18:00 | |
| Hall: | Guerzenich | |
| With: | S. Sauerland | |
| 13:00-14:00 | Aims and definition of Evidence-based Medicine | |
| 14:00-15:00 | Clinical applications: Using evidence at the bedside | |
| 15:15-16:00 | Collecting information: Finding the right study quickly | |
| 16:00-17:00 | Appraising study results: What is credible? | |
| 17:00-17:45 | Applying EbM at a global level: Evidence-based health care | |
| 17:45-18:00 | Discussion and Evaluation | |
Symposium 1
| Title: | Multiple Injury and Coagulation | |
| Date: | Monday, June 30 | |
| Time: | 08:30 - 10:00 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | B. Bouillon R. Roissant | |
| 08:30-08:45 | The clinical problem | B. Bouillon |
| 08:45-09:05 | Mechanism of early coagulopathy | K. Brohi |
| 09:05-09:20 | The role of fibrinogen | W.Z. Martini |
| 09:20-09:35 | The role of platelets | M. Maegele |
| 09:35-10:00 | Discussion | |
Supported by an unrestricted educational grant by Novo Nordisk
Symposium 2
| Title: | Hemodynamic Monitoring of Shock in the 21st Century | |
| Date: | Monday, June 30 | |
| Time: | 08:30 - 10:00 | |
| Hall: | Guerzenich, Horton Hall | |
| Chair: | C.J. Hauser F. Wappler | |
| 08:30-08:45 | Introduction: Choosing the right parameters to monitor in shock | C.J. Hauser |
| 08:45-09:00 | Intermittent ultrasound vs. continuous invasive monitoring | A. Oren-Grinberg |
| 09:00-09:15 | PICCO: Is it as good as U/S or Swan-Ganz? | D. Reuter |
| 09:15-09:30 | NIRS as a global O2 transport monitor | F. Moore |
| 09:30-09:45 | The Swan-Ganz catheter: still there when we need it | C. J. Hauser |
| 09:45-10:00 | Discussion | |
Symposium 3
| Title: | Sepsis - A Worldwide Challenge in Prevention, Diagnosis and Therapy | |
| Date: | Monday, June 30 | |
| Time: | 08:30 - 10:00 | |
| Hall: | Guerzenich, Sayeed Hall | |
| Chair: | J. Marshall U.B. Brueckner | |
| 08:30-09:00 | The challenge of description: Is it sepsis; Is it shock? | J. Marshall |
| 09:00-09:15 | The challenge of diagnosis and staging | K. Reinhart |
| 09:15-09:30 | Sepsis in Latin America | L. P.-de-Figueiredo |
| 09:30-09:45 | Sepsis in China | Y.-M. Yao |
| 09:45-10:00 | Panel Discussion: Points to be discussed as outlined in the Cologne Declaration on Shock | |
Plenary Session I
| Title: | From Analysis to Synthesis: Convergence in Shock Research | |
| Date: | Monday, June 30 | |
| Time: | 10:30 - 12:00 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | T.G. Buchman | |
| 10:30-10:45 | From reductionism to abstraction to modelling | Y. Vodovotz |
| 10:45-11:00 | Crisis and damage control: Is critical illness the result of damage containment failure? | T. Billiar |
| 11:15-11:30 | Integrating the Shock Research Community | G. An |
| 11:30-11:45 | Modularity in shock and recovery | T.G. Buchman |
| 11:45-12:00 | Discussion | |
Lunch Symposium - Brahms
| Title: | Impact of Biomarkers in Assessment and Therapeutic Decisions in Critically ill Patients | |
| Date: | Monday, June 30 | |
| Time: | 12:15 - 13:15 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | E. Kuse | |
| 1. | Pro-ADM in assessment of severity of pneumonia in the emergency department | B. Schuetz |
| 2. | PCT-impact on therapeutic decisions on the ICU | K. Reinhart |
Lunch Symposium - Merck Sharp & Dohme (MSD)
| Title: | Meet the Professors: E. Mueller S. Sakka Severe Fungal Infection in the ICU: Prevention, Recognition and Treatment | |
| Date: | Monday, June 30 | |
| Time: | 12:15 - 13:15 | |
| Hall: | Guerzenich, Horton Hall | |
Lunch Symposium - Codman
| Title: | Perspectives in CBF Monitoring | |
| Date: | Monday, June 30 | |
| Time: | 12:15 - 13:15 | |
| Hall: | Guerzenich, Sayeed Hall | |
| Chair: | A.I.R. Maas | |
| 1. | The significance of CBF monitoring: | G.T. Manley |
| 2. | Advances in CBF monitoring: Introducing the Hemedex thermal diffusion monitor | P. Horn |
Symposium 4
| Title: | Monitoring of Cerebral Blood Flow, Metabolism and Function | |
| Date: | Monday, June 30 | |
| Time: | 15:45 - 17:15 | |
| Hall: | Guerzenich, Sayeed Hall | |
| Chair: | A.I.R. Maas A. Unterberg | |
| 15:45-16:05 | Flow and metabolism in the acute phase after TBI: Is the brain in shock? | D.A. Hovda |
| 16:05-16:25 | Is oxygen extraction compromised after TBI? | J.P. Coles |
| 16:25-16:45 | Application of advanced cerebral monitoring towards individualized therapy | G.T. Manley |
| 16:45-17:00 | Depolarisations in the injured brain: a new finding worth monitoring? | A. Strong |
| 17:00-17:15 | Discussion | |
Supported by INTS and EMN
Symposium 5
| Title: | Multiple Organ Failure - How to prevent? | |
| Date: | Monday, June 30 | |
| Time: | 15:45 - 17:15 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | K. Okada B. Pruitt | |
| 15:45-16:00 | Immune effects of fluids | R. Coimbra |
| 16:00-16:15 | Mechanisms of refractory hypotension in shock | K.-S. Zhao |
| 16:15-16:30 | Fluids vs. vasopressors | J.-L. Vincent |
| 16:30-16:45 | If fluids - which one? | R. Zander |
| 16:45-17:15 | Panel Discussion | |
Symposium 6
| Title: | Cellular Dysfunction in Ischemia, Trauma and Sepsis | |
| Date: | Monday, June 30 | |
| Time: | 15:45 - 17:15 | |
| Hall: | Guerzenich, Horton Hall | |
| Chair: | W. Buurman A. De Maio | |
| 15:45-16:00 | Endothelial Cells | A. De Maio |
| 16:00-16:15 | Stem cell based cellular replacement strategies following traumatic brain injury (TBI) | U. Schaefer |
| 16:15-16:30 | Dendritic Cells | S.B. Flohé |
| 16:30-16:45 | The monocyte/T-cell interaction complex | E. Faist |
| 16:45-17:00 | Microcirculation | M.D. Menger |
| 17:00-17:15 | Discussion | |
Supported by ESTES
Symposium 7
| Title: | Wound Healing in Trauma and Sepsis | |
| Date: | Tuesday, July 1 | |
| Time: | 08:30 - 10:00 | |
| Hall: | Guerzenich, Horton Hall | |
| Chair: | I. Marzi J.A. Lederer | |
| 08:30-08:45 | Posttraumatic systemic inflammation and local wound healing - What is the problem? | I. Marzi |
| 08:45 - 09:00 | The role of infection on wound healing | C. Willy |
| 09:00 - 09:15 | Local and systemic interactions of healing in bums | J.A. Lederer |
| 09:15 -09:30 | Local and systemic approaches to improve wound healing | J. Frank |
| 09:30 -10:00 | Discussion | |
Symposium 8
| Title: | Shock: Age, Gender and Substance Dependence | |
| Date: | Tuesday, July 1 | |
| Time: | 08:30 - 10:00 | |
| Hall: | Guerzenich, Sayeed Hall | |
| Chair: | I. Chaudry L.N. Diebel | |
| 08:30-08:45 | Effect of gender and sex hormones on immune and cardiovascular responses following major trauma-potential clinical application | M.K. Angele |
| 08:45-09:00 | Age-dependent inflammatory response to sepsis and shock | M.G. Jeschke |
| 09:00-09:15 | The status of alcohol in post burn immune complications | M.A. Choudhry |
| 09:15-09:30 | Age and sex hormones: major determinants in altered immune and cardiac functions following burn and trauma | E.A. Deitch |
| 09:30-09:45 | Age and gender based therapeutic intervention for cardiac surgery and trauma | D.R. Meldrum |
| 09:45-10:00 | Discussion | |
Symposium 9
| Title: | Blood Purification in the Treatment of Sepsis | |
| Date: | Tuesday, July 1 | |
| Time: | 08:30 - 10:00 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | H. Hirasawa J.C. Marshall | |
| 08:20-08:45 | Continuous hemodiafiltration with a cytokine-adsorbing hemofilter for the treatment of a patient with septic shock | S. Oda |
| 08:45-09:00 | Comparison of efficacy between continuous hemodiafiltration with a PMMA membrane hemofilter and a PAN membrane hemofilter in the treatment of a patient with septic acute renal failure | K. Matsuda |
| 09:00-09:15 | Endotoxemia and immune profiles of patients with acute sepsis due to major peritonitis | E. Faist |
| 09:15-09:30 | Endotoxin activity assay as the diagnostics for the anti-endotoxin sepsis treatment | D. Klein |
| 09:30- 10:00 | Discussion | |
Supported with grants by Toray Industries and Spectral Diagnostics
Plenary Session II
| Title: | Clinical Trails in Trauma and Sepsis - What can we learn from each other? | |
| Date: | Tuesday, July 1 | |
| Time: | 10:30 - 12:00 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | J.C. Marshall A.I.R. Maas | |
| 10:30-10:45 | A critique of sepsis clinical research | E.A.M. Neugebauer |
| 10:45-11:00 | Metaanalyses of sepsis trials - how can they help? | A. Nierhaus |
| 11:00-11:15 | A critique of trauma clinical research | E.E. Moore |
| 11:15-11:30 | Clinical trials in traumatic brain injury - revisited | A.I.R. Maas |
| 11:30-12:00 | Panel discussion including all led investigators from the research consortia | |
Supported by the International Sepsis Forum
Invited Lecture
| Title: | Studying Shock in Ebola Hemorrhagic Fever, H5N1 Avian Influenza and other Severe Viral Infections | |
| Date: | Tuesday, July 1 | |
| Time: | 12:15 - 13:00 | |
| Hall: | Guerzenich, Schlag Hall | |
| Introduction: | H.D. Klenk | |
| Speaker: | M. Bray | |
Lunch Symposium
| Title: | Translational Research: Perspectives of the Industry | |
| Date: | Tuesday, July 1 | |
| Time: | 13:00 - 14:00 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | E.A.M. Neugebauer | |
| 1. | Bruce Gingles, Cook Medical | |
| 2. | Bartholomew J. Tortella, Novo Nordisk | |
Lunch Symposium - Baxter
| Title: | HES 130/0,42 in Acetate Balanced Electrolyte Solution: A Novel Clinical Approach in the Hypovolemia and Shock Therapy | |
| Date: | Tuesday, July 1 | |
| Time: | 13:00 - 14:00 | |
| Hall: | Guerzenich, Sayeed Hall | |
| Chair: | R. Weidhase | |
| 1. | HES 130/0,42 in acetate buffered Ringer`s solution as a part of a balanced volume resuscitation for abdominal surgery | L.A. Lampl |
| 2. | Effects of artificial colloids on circulation and inflammation in a porcine two-hit model of haemorrhagic and septic shock | G. Marx |
Symposium 10
| Title: | Genomics and Proteomics in Trauma and Sepsis | |
| Date: | Tuesday, July 1 | |
| Time: | 16:00 - 17:30 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | D. Remick | |
| 16:00-16:15 | Genetic polymorphisms in trauma and sepsis | F. Stueber |
| 16:15-16:30 | Multiplex proteomics in trauma for class prediction | D. Remick |
| 16:30-16:45 | Genomics and proteomics for pathogen recognition by the innate immune system | M. Bauer |
| 16:45-17:00 | Changes in the plasma proteome after burn injury | C.C. Finnerty |
| 17:00-17:15 | Genomic expression analysis in trauma: The glue grant experiences | R.V. Maier |
| 17:15-17:30 | Discussion | |
Symposium 11
| Title: | Severe Viral Infections | |
| Date: | Tuesday, July 1 | |
| Time: | 16:00 - 17:30 | |
| Hall: | Guerzenich, Horton Hall | |
| Chair: | M. Bray H.-D. Klenk | |
| 16:00-16:25 | Lethal infection of macaques by 1918 influenza virus | H. Feldmann |
| 16:25-16:50 | Preserving immune function during severe infections | R. Hotchkiss |
| 16:50-17:15 | Patient care in hemorrhagic fever outbreaks | A. Sprecher |
| 17:15-17:30 | Discussion | |
Symposium 12
| Title: | Peroxisome Proliferator-Activated Receptors (PPARs) and Liver X Receptors (LXRs) as Therapeutics Targets in Shock and Inflammation | |
| Date: | Tuesday, July 1 | |
| Time: | 16:00 - 17:30 | |
| Hall: | Guerzenich, Sayeed Hall | |
| Chair: | B. Zingarelli J.A. Cook | |
| 16:00-16:15 | Intracellular signaling systems: Overview | J.A. Cook |
| 16:15-16:30 | PPAR-alpha and PPAR-gamma: a cooperative role in reperfusion injury | C. Thiemermann |
| 16:30-16:45 | Novel PPAR-gamma activators | P. Wang |
| 16:45-17:00 | PPAR-gamma bridging the gap between the bench and the bedside | B. Zingarelli |
| 17:00-17:15 | Closing remarks and panel discussion | J.A. Cook |
| 17:15-17:30 | Discussion | |
Symposium 13
| Title: | Organ Injury - Treatment Priorities | |
| Date: | Wednesday, July 2 | |
| Time: | 08:00 - 09:30 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | C.J. Hauser H.-C. Pape | |
| 08:00-08:15 | The early prioritization of multiple bleeding injuries | C.J. Hauser |
| 08:15-08:30 | The physiology and immunology of fracture fixation | H.-C. Pape |
| 08:30-08:45 | Damage control orthopedics vs. early total care | D. Rixen |
| 08:45-09:00 | Intracranial injury in the setting of multiple trauma | D.H. Livingston |
| 09:00-09:15 | Panel Discussion - The integration of early trauma care: Future outcome studies: How we should structure them | |
Symposium 14
| Title: | Lung Inflammation - New Insights | |
| Date: | Wednesday, July 2 | |
| Time: | 08:00 - 09:30 | |
| Hall: | Guerzenich, Horton Hall | |
| Chair: | R. Rabinovici M. Huber-Lang | |
| 08:00-08:15 | Cellular interactions of epithelium and endothelium at the alveolocapillary barrier | C. J. Kirkpatrick |
| 08:15-08:30 | Early vs. delayed ARDS | J.L. Vincent |
| 08:30-08:45 | Reversibility of lung collapse and hypoxemia | M. Amato |
| 08:45-09:00 | A-to I RNA editing and lung inflammation | R. Rabinovici |
| 09:00-09:15 | ARDS-Sepsis relationship | P.A. Ward |
| 09:15-09:30 | Discussion | |
Symposium 15
| Title: | Organ Failure in Sepsis - An Adaptive Response? | |
| Date: | Wednesday, July 2 | |
| Time: | 08:00 - 09:30 | |
| Hall: | Gürzenich, Sayeed Hall | |
| Chair: | C. Deutschman H. Redl | |
| 08:00-08:15 | Sepsis induces alterations in organ function, not structure | R. Hotchkiss |
| 08:15-08:30 | Sepsis alters signal transduction, but not the proteins involved | C.S. Deutschman |
| 08:30-08:45 | Hypothermia/hibernation induces an adaptive, sepsis-like state | K.H. Polderman |
| 08:45-09:00 | The mithchondria is the sensor that activates organ dysfunction | R.J. Levy |
| 09:00-09:30 | Discussion | |
Young Investigator Award Competition of the
IFSS, US Shock Society and ESS
| Date: | Wednesday, July 2 | ||
| Time: | 09:45 - 12:00 | ||
| Hall: | Guerzenich, Schlag Hall | ||
| Chair: | P. Wischmeyer Members of the ESS-Award Committee Members of the IFSS-Award Committee | ||
| IFSS 09:45-10:00 | Dietary lipids reduce inflammation via peripheral activation of the autonomic nervous system | T. Lubbers, Maastricht, The Netherlands | |
| IFSS 10:00-10:15 | α7 Nicotine acetylcholine receptor stimulation inhibits cytokine release in human whole blood stimulated with various toll-like receptoragonists | M. Kox, Nijmegen, The Netherlands | |
| ESS 10:15-10:30 | Platelet factor 4 (PF4) gene expression is highly upregulated in dendritic cells after severe trauma | E.V. Geiger, Frankfurt/M., Germany | |
| ESS 10:30-10:45 | Insulin decreases systemic bacterial dissemination and improves survival after burn wound infection | G.G. Gauglitz, Galvestone, USA | |
| US SS 10:45-11:00 | Estrogen suppresses cardiac IL-6 after trauma-hemorrhage via HIF-1α pathway | E.A. Nickel, Birmingham, USA | |
| US SS 11:00-11:15 | Trauma-shock lymph-induced lung injury occurs via the TLR-4 pathway | V. Pisarenko, Newark, USA | |
| US SS 11:15-11:30 | Lactate clearance as a determinant of survival in patients with severe sepsis | R.C. Arnold, Cooper, USA | |
| US SS 11:30-11:45 | Caffeine restores myocardial cytochrome oxidase activity and cardiac function during sepsis | R. Verma, Valhalla, USA | |
| US SS 11:45-12:00 | Modulation of BCL-2 family blocks sepsis-induced depletion of dendritic cells and macrophages | O. Peck-Palmer, St. Louis, USA | |
The Cologne Declaration on Shock (IFSS)
| Date: | Wednesday, July 2 |
| Time: | 12:15 - 13:00 |
| Hall: | Guerzenich, Schlag Hall |
| Organizer: | E.A.M. Neugebauer |
Mini-Symposium
| Title: | Presentation of Best Abstracts | ||
| Date: | Wednesday, July 2 | ||
| Time: | 12:00 - 13:15 | ||
| Hall: | Guerzenich, Horton Hall | ||
| Chair: | M.M. Krausz W. Junger | ||
| 12:00-12:10 | Translation of the treatment of hemorrhagic shock from the bench to the bedside in civilian as well as military patients (Abstract 14) | M.M. Krausz, Haifa, Israel | |
| 12:10-12:20 | The non-genomic pathway mediates some of the effects of estrogen on cytokine production by T-cells following trauma-hemorrhage (Abstract 15) | T. Suzuki, Birmingham, USA | |
| 12:20-12:30 | Increased endothelial progenitor cell sepsis (Abstract 16) | A. Matsushima, Osaka, Japan | |
| 12:30-12:40 | In vivo gene silencing of peroxisome proliferator activated receptor-y enhances myocardial reperfusion injury (Abstract 10) | B. Zingarelli, Cincinnati, USA | |
| 12:40-12:50 | Early norepinephrine infusion delays cardiac arrest after severe hemorrhagic shock in rats (Abstract 11) | J. H. Lee, Seoul, Korea | |
| 12:50 - 13:00 | Humanized mice as a powerful tool to study the effects of sepsis on human hematopoietic cells (Abstract 13) | J. Unsinger, St. Louis, USA | |
Novo Nordisk Award Session
| Title: | ||
| Date: | Tuesday, July 1 | |
| Time: | 13:00 - 14:00 | |
| Hall: | Guerzenich, Sayeed Hall | |
| Chair: | H. Redl C. J. Hauser | |
| 12:00-12:15 | Interaction of the coagulation and complement system during hemorrhagic shock | M. Huber-Lang |
| 12:15-12:30 | Prospective multicenter study of the relationship between global tissue hypocia and coagulation activation in early sepsis resuscitation | S.Trzeciak |
| 12:30-12:45 | Role of hem oxygenase induction in the early phase of reperfusion after trauma/hemorrhagic shock in rats | C. Duvigneau |
| 12:45-13:00 | Towards a mouse model for acute coagulopathy of trauma/shock | R.M. Pearse |
Symposium 16
| Title: | Trauma Registries and Outcome | |
| Date: | Wednesday, July 2 | |
| Time: | 13:15 - 14:45 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | D.B. Hoyt P. Biberthaler | |
| 13:15-13:30 | Trauma registries and outcome | R. Lefering |
| 13:30-13:45 | European guidelines coagulation | R. Roissant |
| 13:45-14:00 | Glue grant standardized guidelines (SOPs) for trauma patient care | R.V. Maier |
| 14:00-14:15 | Use of the German trauma registry: Identified the sickest patients | B. Bouillon |
| 14:14-14:30 | The trauma registry from Iraq: Uses and early results | J.B. Holcomb |
| 14:30-14:45 | Discussion | |
Symposium 17
| Title: | Burn Injury | |
| Date: | Wednesday, July 2 | |
| Time: | 13:15 - 14:45 | |
| Hall: | Guerzenich, Sayeed Hall | |
| Chair: | M.G. Jeschke | |
| 13:15-13:30 | The use of β-blocking agents to ameliorate postburn catabolism | M.G. Jeschke |
| 13:30-13:45 | Burns and inhalation injury | D.L. Traber |
| 13:45-14:00 | Regenerative medical tools to treat postburn skin loss | H.-G. Machens |
| 14:00-14:15 | Genomic and proteomic alterations post burn - possible implications for existing and new therapies | M.G. Jeschke |
| 14:15-14:30 | ER stress and changes in intracellular calcium signaling postburn - basic research and clinical applicability | D.F. Boehning |
| 14:30-14:45 | Discussion | |
Symposium 18
| Title: | Cardiac Effects of Injury and Sepsis | |
| Date: | Wednesday, July 2 | |
| Time: | 13:15 - 14:45 | |
| Hall: | Guerzenich, Horton Hall | |
| Chair: | U.F. Schade K. Werdan | |
| 13:15-13:30 | Myocardial suppression after burns and trauma | E.A. Deitch |
| 13:30-13:45 | The role of inflammation in acute heart failure and cardiogenic shock | K. Werdan |
| 13:45-14:00 | The cardiac cholinergic anti-inflammatory reflex in MODS | H. Schmidt |
| 14:00-14:15 | Endotoxin inhibits the pacemaker current lf | K. Zorn-Pauly |
| 14:15-14:30 | IgM-enriched human intravenous immunoglobulin attenuate microvascular perfusion failure in endotoxaemia | J.N. Hoffmann |
| 14:30-14:45 | Discussion | |
Symposium 19
| Title: | New Directions in the Management of Trauma Induced Coagulopathy | |
| Date: | Wednesday, July 2 | |
| Time: | 15:15 - 17:00 | |
| Hall: | Guerzenich, Schlag Hall | |
| Chair: | D.B. Hoyt J.R. Hess | |
| 15:15-15:30 | Current practice of the management of coagulopathy - the reallity today | D.B. Hoyt |
| 15:30-15:45 | Rapid prediction of massive transfusion | C.E. Wade |
| 15:45-16:00 | Past vs. current resucitation paradigms | W. Junger |
| 16:00-16:15 | Looking to the future of resuscitation | J.B. Holcomb |
| 16:15-16:30 | New blood products within the next five years | J.R. Hess |
| 16:30-17:00 | Discussion | |
Supported with an unrestricted educational grant by Novo Nordisk
Symposium 20
| Title: | ICU Care of the Future | |
| Date: | Wednesday, July 2 | |
| Time: | 15:15 - 17:00 | |
| Hall: | Guerzenich, Sayeed Hall | |
| Chair: | M. Bauer | |
| 15:15-15:30 | Interdisciplinary ICU-centeres vs. specialized IDU units - impact on quality and costs | S.G. Sakka |
| 15:30-15:45 | E-ICU - no need for the intensivist at the bedside? | A. Seiver |
| 15:45-16:00 | Patient data monitoring systems - impact on quality control and cost effectiveness | |
| 16:00-16:15 | Future of cardio-respiratory monitoring | T. G. Buchman |
| 16:15-16:30 | Theragnostics in the ICU - What makes the difference? | M. Bauer |
| 16:30-17:00 | Discussion | |
In cooperation with the German Sepsis Society
Symposium 21
| Title: | The Benefits and Limitations of Antibiotic Prophylaxis and Therapy | |
| Date: | Wednesday, July 2 | |
| Time: | 15:15 - 17:00 | |
| Hall: | Guerzenich, Horton Hall | |
| Chair: | T. Welte K.W. Jauch | |
| 15:15-15:30 | PCR Microbiology and/or conventional blood culture | F. Stueber |
| 15:30-15:45 | Use of biomarkers to guide antibiotic therapy | P. Schuetz |
| 15:45-16:00 | Diagnosis of invasive mycosis in the ICU: What do we gain from non-culture based methods? | W. Meersseman |
| 16:00-16:15 | Fungal infection in the ICU - new treatment strategies | M. Kochanek |
| 16:15-16:45 | Discussion | |